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CD44 is activated by binding to its primary ligand, HA, which triggers downstream signaling

However, this work once again highlights the remarkable metabolic plasticity of tumour cellsa key aspect of cancer biologywhich allows them to adapt to adverse nutritional conditions and, in many cases, to develop therapy resistance

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Scalise M, Pappacoda G, Mazza T, Console L,Pochini L,Indiveri C

Epitalon was also found to downregulate HER-2/neu gene expression, likely through modulation of chromatin structure or transcriptional regulation